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2014, :. doi:
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Adrenomedullin: a vasodilator to treat sepsis?
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[(plays) -304.8 (a) -301.3 (role) -299.5 (in) -304.1 (vascular) -308.6 (tone) -300 (homeo) -7.4 (stasis.) -302.2 (In) -304.1 (the) ] TJ
0 -1.1962 TD
[(previous) -304.1 (issue) -304.4 (of) ] TJ
/F4 1 Tf
7.0185 0 TD
[(Critical) -297 (Care) ] TJ
/F3 1 Tf
4.6261 0 TD
[(,) -298.9 (t) 0 (h) -6.1 (e) -297.7 (infusion) -305.3 (of) ] TJ
-11.6447 -1.2019 TD
[(exogenous) -308.2 (adrenomedullin) -311.8 (is) -301.1 (suggested) -308.1 (to) -300.9 (protect) ] TJ
T*
[(against) -306.5 (increased) -304.9 (lung) -303.3 (endothe) -7.6 (lial) -301 (permeab) -10 (ility) -298.1 (and) ] TJ
0 -1.1962 TD
[(end-organ) -307.1 (dysfunction) -310 (in) -298.5 (a) -301.3 (model) -303.4 (of) -303.2 (pneum) -8.4 (ococcal) ] TJ
0 -1.2019 TD
[(pneumonia) -304 (in) -304.1 (mechanicall) -11.6 (y) -300 (ventilated) -308 (mice,) ] TJ
T*
[(possibly) -304 (by) -303.3 (stabilizing) -310.4 (vascular) -308.6 (endothelia.) -305.3 (Since) ] TJ
0 -1.1962 TD
[(adrenomedullin) -311.8 (is) -301.1 (a) -301.3 (strong) -303 (vasodilatory) -314.4 (molecule,) ] TJ
0 -1.2019 TD
[(further) -302.4 (studies) -306.1 (are) -302.4 (neede) -8.2 (d) -298 (t) 0 (o) -300.9 (evaluate) -310.7 (its) -299.5 (potential) -306.2 (as) ] TJ
T*
[(a) -301.3 (future) -303.9 (treatment) -307 (of) -303.2 (sepsis.) ] TJ
/F5 1 Tf
9.7999 0 0 9.7999 56.6929 330.7464 Tm
[(In) -468.7 (th) 12.6 (e) -478.6 (p) 0 (r) 15.1 (evi) 13.8 (ou) 13.9 (s) -477 (i) 0 (s) 14.4 (s) 0 (u) 17.7 (e) -484.4 (o) 10.9 (f) ] TJ
/F6 1 Tf
10.8296 0 TD
[(Crit) 18.4 (ic) 15.9 (al) -472.3 (Car) 15.8 (e) ] TJ
/F5 1 Tf
5.5478 0 TD
.4762 Tc
[(,M) 476.2 492.1 (l) 476.2 (l) 492.9 (e) 476.2 (r) 511.4 (-) 476.2 (R) 493.9 (e) 476.2 (d) 488.1 (e) 476.2 (t) 493.1 (z) 476.2 (k) 493.4 (y) ] TJ
-16.3774 -1.2264 TD
0 Tc
[(an) 15.5 (d) -695.4 (c) 0 (o) 12.5 (l) 11.2 (le) 12.8 (ag) 17.7 (ue) 16.1 (s) -702.6 (p) 0 (r) 20.9 (o) 0 (p) 15.5 (o) 0 (s) 14.1 (e) -698.4 (th) 12.6 (at) -688.8 (ad) 17.7 (re) 12.1 (no) 19.1 (me) 13.1 (du) 13.3 (l) 11.2 (l) 0 (i) 16.7 (n) -697.6 (ma) 13.1 (y) -698.4 (b) 10.9 (e) ] TJ
0 -1.2206 TD
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0 -1.2264 TD
[(am) 13.1 (i) 11.2 (n) 0 (o) -304.8 (a) 0 (c) 14.7 (i) 0 (d) -302.4 (p) 0 (o) 15.5 (l) 0 (y) 12.8 (p) 0 (e) 17.7 (p) 0 (t) 14.2 (i) 0 (d) 15.8 (e) -310.8 (sh) 12 (o) 10.9 (w) 0 (i) 14 (n) 0 (g) -305.3 (s) 0 (e) 16.3 (q) 0 (u) 13.3 (e) 0 (n) 15.5 (c) 0 (e) -303.5 (h) 0 (o) 13.9 (m) 11.5 (ol) 10.6 (o) 10.9 (g) 0 (y) -306.2 (w) 0 (i) 14 (t) 0 (h) ] TJ
T*
[(ot) 14.7 (he) 16.1 (r) -353.9 (c) 0 (a) 14.7 (l) 11.2 (ci) 12.8 (to) 20.5 (ni) 13.7 (n-) 13.5 (re) 17.9 (l) 11.2 (a) 0 (t) 11.2 (e) 0 (d) -341 (p) 0 (e) 11.9 (p) 0 (t) 19.9 (i) 0 (d) 15.8 (es,) -355.8 (di) 15.8 (sc) 16.3 (ov) 11.9 (er) 17.9 (ed) -346.8 (20) -342.1 (ye) 14.7 (ar) 17.9 (s) -349.7 (a) 0 (g) 12 (o) ] TJ
0 -1.2206 TD
[(as) -625.8 (a) -640.6 (sec) 12.1 (re) 17.9 (ti) 15.1 (o) 10.9 (n) -628.1 (pr) 15.1 (o) 10.9 (d) 0 (u) 13.3 (c) 0 (t) -619.4 (o) 10.9 (f) -628.8 (a) -623.2 (ph) 13.3 (eo) 18.2 (ch) 10.3 (ro) 21.5 (mo) 10.9 (cy) 14.7 (to) 14.7 (m) 11.5 (a) 0 (.) -619.3 (T) 18.1 (he) ] TJ
0 -1.2264 TD
[(ad) 17.7 (re) 12.1 (no) 19.1 (me) 13.1 (du) 13.3 (l) 11.2 (l) 0 (i) 16.7 (n) -396.7 (ge) 12 (ne) -389.4 (en) 15.5 (co) 12.5 (de) 17.7 (s) -396 (f) 0 (o) 12.7 (r) -394.4 (a) -403.4 (1) 0 (8) 16.5 (5) -396.7 (am) 13.1 (i) 11.2 (n) 0 (o) -391.6 (a) 0 (c) 14.7 (i) 11.2 (d) -400.4 (p) 0 (r) 15.1 (e) 0 (-) ] TJ
T*
[(pr) 15.1 (o) 10.9 (p) 0 (e) 11.9 (p) 0 (t) 20 (i) 0 (d) 15.8 (e) 0 (,) -411 (p) 0 (o) 15.5 (s) 0 (t) 35.9 (-) 11.1 (tr) 14.4 (an) 15.5 (sc) 16.3 (ri) 16 (pt) 14.2 (i) 11.2 (o) 0 (n) 13.3 (a) 0 (l) 18.6 (l) 0 (y) -409.5 (c) 0 (l) 18.6 (e) 0 (a) 26.2 (v) 0 (e) 14.1 (d) -417.7 (to) -407.6 (pr) 20.9 (od) 15.5 (uc) 10.3 (e) -415 (t) 0 (h) 18.4 (e) ] TJ
0 -1.2206 TD
[(bi) 16.4 (oa) 12.5 (ct) 16.9 (i) 11.2 (v) 0 (e) 14.1 (,) -262.2 (am) 13.1 (i) 11.2 (d) 0 (a) 11.9 (t) 0 (e) 16.9 (d) -261.5 (ad) 17.7 (re) 12.1 (no) 19.1 (me) 13.1 (du) 13.3 (l) 11.2 (l) 0 (i) 16.7 (n) 0 (.) ] TJ
.8157 -1.2264 TD
[(Adren) -7.6 (omedu) -9 (llin) -293.6 (is) -292.2 (found) -301.3 (in) -292.9 (pla) -11.6 (sma) -296.1 (in) -298.7 (health) -299.8 (and) -292.3 (at) -295.5 (el-) ] TJ
-.8157 -1.2264 TD
[(e) -10 (vate) -9.5 (d) -452.5 (concent) -10.5 (rations) -459.6 (during) -466.9 (various) -456.1 (patho) -10.9 (logic) -452.2 (con) -8.3 (di-) ] TJ
0 -1.2206 TD
[(tions) -26.3 (,) -811.7 (including) -815.5 (cardiov) -10.7 (a) -10 (scular) -813.6 (and) -813 (renal) -811.5 (disorde) -11.3 (rs) -21 (,) ] TJ
0 -1.2264 TD
[(sepsis) -25.2 (,) -447.3 (cancer) 65.4 (,) -447.3 (and) -448.5 (diabete) -11.1 (s) -448 ([) 3.8 (2].) -452.5 (T) 12.3 (his) -451.2 (polypeptide) -460.6 (ha) -12.8 (s) -442.3 (a) ] TJ
T*
[(potent) -684.5 (va) -9 (sodil) -10.9 (ating) -676.3 (effe) -16.6 (ct) -677.3 (and) -679.9 (is) -674 (belie) -15.6 (ved) -681.3 (to) -679.5 (play) -675.3 (a) ] TJ
0 -1.2206 TD
[(physiolo) -12.8 (gical) -872.3 (role) -874 (in) -871.4 (arterial) -873.6 (pressu) -8.7 (re) -867.2 (hom) -9.3 (eosta) -19.5 (sis.) ] TJ
0 -1.2264 TD
[(Adren) -7.6 (omedu) -9 (llin) -438.2 (exert) -14.2 (s) -436.5 (i) 0 (t) -13.9 (s) -436.5 (effe) -16.5 (ct) -12 (s) -436.5 (via) -443.2 (it) -8.1 (s) -436.5 (lig) -7.6 (ation) -438.6 (to) -442.3 (the) ] TJ
T*
[(G-cou) -9.6 (pled) -776.4 (se) -12.6 (ven-t) -9.1 (ransme) -9.7 (mbrane) -794.6 (calcitonin) -786.7 (re) -11 (cepto) -12.3 (r) 22.1 (-) ] TJ
ET
q
56.693 120.132 m
290.551 120.132 l
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56.693 93.94 l
W
n
0 0 0 1 K
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1 0 0 1 56.693 120.076 cm
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233.858 0 l
S
Q
Q
BT
/F3 1 Tf
7.4999 0 0 7.4999 56.6929 111.9685 Tm
0 0 0 rg
[(Correspondenc) -13.8 (e:) ] TJ
0 0 0 1 k
7.0678 0 TD
[(jerome.pugin@unig) -16.2 (e.ch) ] TJ
0 0 0 rg
-7.0678 -1.2019 TD
[(Intensive) -306.1 (Care) -307.3 (Division,) -305.2 (University) -303.3 (Ho) -8.1 (spitals) -302.4 (of) -297.5 (Gen) -8.8 (eva,) -297.9 (CH-121) -10.4 (1) -299.6 (Geneva) -306.3 (14,) ] TJ
T*
(Switzerland) Tj
ET
/EmbeddedDocument /MC1 BDC
/Document /MC2 BDC
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EMC
EMC
Q
BT
/F5 1 Tf
9.7999 0 0 9.7999 304.7243 577.7573 Tm
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0 -1.2264 TD
[(R) -33.9 (A) -20.9 (MP2) -411.8 (or) -406.6 (R) -33.9 (A) -20.9 (MP3) -411.8 (to) -407.6 (form) -410.7 (the) -408.2 (adren) -8.3 (omedul) -9.3 (lin) -403.2 (re) -16.8 (cep-) ] TJ
0 -1.2206 TD
[(tors) -417 (1) -408.2 (and) -413.8 (2,) -410.1 (res) -7.9 (pe) -11.2 (ctively.) -421.1 (Numerous) -422.8 (pleiotro) -10.4 (pic) -410.7 (effe) -16.6 (ct) -12 (s) ] TJ
0 -1.2264 TD
[(of) -843.5 (adrenomedu) -11.5 (llin) -843.2 (ha) 10.3 (ve) -842.1 (been) -845.5 (described:) -848.9 (in) -842.5 (tumor) ] TJ
T*
[(growth) -10.6 (,) -985.3 (neova) -17.3 (sculariz) -18.2 (ation,) -990.1 (endo) -9.5 (thelium) -990.2 (prote) -20.7 (ction,) ] TJ
0 -1.2206 TD
[(bronchodi) -15 (lation,) -307.8 (fertility,) -309.6 (and) -303.9 (immu) -9 (nity) -304.9 ([3].) ] TJ
.8157 -1.2264 TD
[(Interest) -10.4 (ingly,) -358.4 (the) -356.1 (pla) -11.6 (sma) -354 (con) -8.3 (centration) -360.9 (of) -357.6 (a) -351.3 (byprod) -9 (uct) ] TJ
-.8157 -1.2264 TD
[(of) -415.4 (the) -419.7 (preproadr) -10.1 (enomedu) -10.8 (llin) -415.1 (cleavage,) -416.9 (the) -414 (mid) -7.4 (-regional) ] TJ
0 -1.2206 TD
[(proad) -8.4 (renomedu) -11.8 (llin,) -781.4 (ha) -12.8 (s) -777.8 (bee) -9.1 (n) -778.6 (used) -786.1 (a) -10 (s) -777.8 (a) -785.2 (prognostic) ] TJ
0 -1.2264 TD
[(marker) 67.1 (,) -337.4 (alone) -342.6 (or) -337.2 (in) -339.2 (risk) -348.6 (stratifica) -13.4 (tion) -336.1 (with) -343.6 (other) -340.4 (prope) -8.4 (p-) ] TJ
T*
[(tides) -380.6 (such) -382.7 (a) -10 (s) -378.6 (procalc) -10.2 (itonin,) -382.1 (in) -379.7 (children) -382 (and) -379.1 (in) -379.7 (adult) -380.8 (pa-) ] TJ
0 -1.2206 TD
.0001 Tc
[(tient) -17.6 (s) -760.3 (with) -765.8 (sepsis) -765.6 (and) -760.8 (se) -12.5 (vere) -760.5 (pne) -8.7 (umonia) -763.4 ([4].) -764.8 (T) 12.4 (his) ] TJ
0 -1.2264 TD
0 Tc
[(biomark) -10.3 (er) -300.3 (is) -303.7 (now) -302.1 (comm) -10.8 (ercially) -308.2 (available.) ] TJ
.8157 -1.2264 TD
[<4DFC6C> -7.5 (ler) 17.5 (-Redetzky) -438.1 (and) -431.1 (colle) -9.8 (agues) -437.3 (propose) -434 (tha) -9 (t) -430.1 (adreno) -9 (-) ] TJ
-.8157 -1.2206 TD
[(medu) -8.3 (llin) -513.4 (treatme) -11.9 (nt) -508.6 (is) -517.8 (beneficial) -523.5 (in) -512.8 (a) -513.3 (mouse) -519.4 (model) -515.6 (of) ] TJ
0 -1.2264 TD
[(pneumoc) -10.8 (occal) -545.9 (pneumon) -9.9 (ia) -536.8 (and) -541.1 (vent) -8.6 (ilator) 14.6 (-indu) -8.2 (ced) -536.1 (lung) ] TJ
T*
[(injury) -560.1 ([1].) -556.7 (In) -555.5 (a) -553.8 (pre) -12.3 (vious) -560.8 (report) -15.9 (,) -557.2 (the) -552.8 (same) -560.7 (group) -562.2 (had) ] TJ
0 -1.2206 TD
[(alread) -9.5 (y) -299.3 (show) -9.1 (n) -304.2 (that) -306 (adren) -8.3 (omedu) -9 (llin) -305.2 (treatme) -11.9 (nt) -300.4 (atten) -10 (uated) ] TJ
0 -1.2264 TD
[(venti) -8.9 (lator) 14.9 (-induced) -301.4 (lung) -291.1 (injury) -299.8 (in) -292.9 (mice) -298.1 ([5].) -290.6 (A) -15.1 (s) -291.8 (ha) -12.8 (s) -291.8 (alread) -9.5 (y) ] TJ
T*
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(2014,) Tj
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2.3792 0 TD
(18:) Tj
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1.2174 0 TD
(R73.) Tj
-22.4388 -1.2019 TD
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-8.2753 -1.1943 TD
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(2002,) Tj
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(221:) Tj
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(1) Tj
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<96> Tj
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-14.7683 -1.2019 TD
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(2006,) Tj
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(80:) Tj
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2.1086 -1.1943 TD
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2.1086 -1.1943 TD
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-8.7766 -1.2019 TD
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(Thorax) Tj
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(2010,) Tj
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2.1086 -1.2019 TD
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-7.9332 -1.1944 TD
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2.1086 -1.2019 TD
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2.1086 -1.1943 TD
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T*
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-11.0511 -1.1649 TD
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